I was appointed at the University of Vienna as a full professor heading CUBE, the Division of Computational Systems Biology, by March 2010. My work and experience cover a wide spectrum of topics from bioinformatics, genome and metagenome analysis and systems biology. My team is developing and applying computational methods for the interpretation of large-scale sequence information. We are involved in numerous international (meta-) genome sequencing and analysis consortia. Our research activities not only cover individual, project-specific questions but also general problems in bioinformatics, computational infrastructure and large-scale biological databases. Furthermore, my group develops novel computational approaches for studying molecular inter-species interactions, such as between hosts and pathogens, between symbionts or in microbial ecosystems.